Creative Peptides has gained extensive experience in the synthesis, modification and purification of peptide nucleic acids. We provide PNA monomers, which are part of PNA oligomers.
- Fmoc PNA Monomers
The PNA monomer synthesized by Fmoc strategy avoids strong corrosiveness and has high quality.
- Boc PNA Monomers
Using Boc synthesis technology can quantify PNA monomer and increase the yield.
- Modified PNA Monomers
The modified PNA monomer has better performance.
PNA was designed and synthesized in 1991 by Nielsen et al. in the Riso lab at the University of Copenhagen using a simple computer DNA model. Synthesis of PNA starts with PNA monomers, followed by oligomerization of PNA monomers following standard peptide synthesis.
PNA replaces the sugar-phosphate backbone with a pseudo-peptide bond, retaining the original four bases. PNA is similar to DNA in morphology and spatial structure. The PNA oligomer chain has a free amino group(-NH3) at one end and a free carboxyl group(-COOH) at the other end, for the 5' and 3' ends of the DNA, respectively.
Fig.1 PNA monomer.
Advantages of PNA
- Strong binding: PNA is composed of an electrically neutral amide backbone, so there is no repulsion between the PNA strand and the DNA strand.
- Strong specificity and sensitivity: the PNA sequence is specific to the target site. If there is one mismatch, the binding affinity is greatly reduced. If there are two mismatches, no hybridization occurs.
- High stability: PNA is highly stable under high temperature and strong PH conditions. PNA is not easily degraded by nucleases and proteases.
- High hybridization stability: PNA is highly stable in hybridization solutions with high salt concentration and also has strong binding power.
- High security: PNA is virtually non-toxic.
Notice: Products and services are used only for scientific research.