Telomere Probes

Products

Telomere Probes

Creative Peptides' PNA Telomere Probes are efficient tools for the detection and regulation of full-length telomeric particles in a wide range of organisms.

Browse our catalog below to find your products of interest.

Structure	Product Name / CAS / Cat	Description / Size	Price
	TelC-Alexa488 CAS:TP-001 Catalog:TP-001	Size:5 nmol
	TelG-Alexa488 CAS:TP-002 Catalog:TP-002	Size:5 nmol
	TelC-Alexa647 CAS:TP-003 Catalog:TP-003	Size:5 nmol
	TelG-Alexa647 CAS:TP-004 Catalog:TP-004	Size:5 nmol
	TelC-Biotin CAS:TP-005 Catalog:TP-005	Size:5 nmol
	TelG-Biotin CAS:TP-006 Catalog:TP-006	Size:5 nmol
	TelC-Cy3 CAS:TP-007 Catalog:TP-007	Size:5 nmol
	TelG-Cy3 CAS:TP-008 Catalog:TP-008	Size:5 nmol
	TelC-Cy5 CAS:TP-009 Catalog:TP-009	Size:5 nmol
	TelG-Cy5 CAS:TP-010 Catalog:TP-010	Size:5 nmol
	TelC-FAM CAS:TP-011 Catalog:TP-011	Size:5 nmol
	TelG-FAM CAS:TP-012 Catalog:TP-012	Size:5 nmol
	TelC-FITC CAS:TP-013 Catalog:TP-013	Size:5 nmol
	TelG-FITC CAS:TP-014 Catalog:TP-014	Size:5 nmol
	TelC-TAMRA CAS:TP-015 Catalog:TP-015	Size:5 nmol
	TelG-TAMRA CAS:TP-016 Catalog:TP-016	Size:5 nmol
	Telomere PNA Kit CAS:K5327 Catalog:TP-017	Size:20 tests
	aTelC-Alexa488 CAS:TP-018 Catalog:TP-018	Alexa Fluor 488 labeled TelC probe Size:5 nmole

Fluorescence in situ hybridization (FISH) is an important non-radioactive in situ hybridization technology. It follows the principle of complementary base pairing. Probes containing fluorescent substances are spliced to the target DNA by special means. Finally, the position of target DNA can be directly observed by fluorescence microscopy. Telomere is a specialized structure consisting of multiple, short repetitive non-transcribed sequences (TTAGGG) and binding proteins. Telomeres are present at the ends of linear chromosomes in eukaryotes. All known eukaryotic telomeres contain simple repeats rich in G and C complementary strands. These telomeric repeats have a general structure (T or A)m(G)n.

Telomere function:

Telomeres protect chromosomes from degradation and DNA repair activities.
Telomeres provide a buffer for non-transcribed DNA outside.
It is involved in chromosome positioning, replication, protection and control of cell growth and lifespan.
It is closely related to apoptosis, cell transformation and immortalization.

Repeated sequences in telomeres are useful candidates for synthetic telomere FISH probes, also known as TeloFISH probes.

Peptide nucleic acid (PNA) is a novel DNA analogue. PNA can recognize and bind DNA or RNA sequences to form a stable double helix structure.

PNA probes have additional advantages compared to DNA probes (Fig. 1).

Fig. 1 Parameter comparison of DNA and PNA.

PNAs are very effective as FISH probes, even at very low concentrations. PNA probe binds to the target sequence rapidly (within a few hours) with much less interfering background.

TelG is a G-rich telomeric probe designed to detect lagging strands (TTAGGG repeats).

TelC is a C-rich telomere probe designed to detect leading strands (TAACCC repeat).

Both TelC and TelG PNA telomere probes are apply to rat chromosomes, human and mouse.

For Research Use Only. Not For Clinical Use.