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Telomere Probes

Telomere Probes

Creative Peptides' PNA Telomere Probes are efficient tools for the detection and regulation of full-length telomeric particles in a wide range of organisms.

Browse our catalog below to find your products of interest.

Structure Product Name / CAS / Cat Description / Size Price
TelC-Alexa488 CAS:TP-001
Catalog:TP-001
Size:5 nmol
TelG-Alexa488 CAS:TP-002
Catalog:TP-002
Size:5 nmol
TelC-Alexa647 CAS:TP-003
Catalog:TP-003
Size:5 nmol
TelG-Alexa647 CAS:TP-004
Catalog:TP-004
Size:5 nmol
TelC-Biotin CAS:TP-005
Catalog:TP-005
Size:5 nmol
TelG-Biotin CAS:TP-006
Catalog:TP-006
Size:5 nmol
TelC-Cy3 CAS:TP-007
Catalog:TP-007
Size:5 nmol
TelG-Cy3 CAS:TP-008
Catalog:TP-008
Size:5 nmol
TelC-Cy5 CAS:TP-009
Catalog:TP-009
Size:5 nmol
TelG-Cy5 CAS:TP-010
Catalog:TP-010
Size:5 nmol
TelC-FAM CAS:TP-011
Catalog:TP-011
Size:5 nmol
TelG-FAM CAS:TP-012
Catalog:TP-012
Size:5 nmol
TelC-FITC CAS:TP-013
Catalog:TP-013
Size:5 nmol
TelG-FITC CAS:TP-014
Catalog:TP-014
Size:5 nmol
TelC-TAMRA CAS:TP-015
Catalog:TP-015
Size:5 nmol
TelG-TAMRA CAS:TP-016
Catalog:TP-016
Size:5 nmol
Telomere PNA Kit CAS:K5327
Catalog:TP-017
Size:20 tests
aTelC-Alexa488 CAS:TP-018
Catalog:TP-018
Alexa Fluor 488 labeled TelC probe Size:5 nmole

Fluorescence in situ hybridization (FISH) is an important non-radioactive in situ hybridization technology. It follows the principle of complementary base pairing. Probes containing fluorescent substances are spliced to the target DNA by special means. Finally, the position of target DNA can be directly observed by fluorescence microscopy. Telomere is a specialized structure consisting of multiple, short repetitive non-transcribed sequences (TTAGGG) and binding proteins. Telomeres are present at the ends of linear chromosomes in eukaryotes. All known eukaryotic telomeres contain simple repeats rich in G and C complementary strands. These telomeric repeats have a general structure (T or A)m(G)n.

Telomere function:

  • Telomeres protect chromosomes from degradation and DNA repair activities.
  • Telomeres provide a buffer for non-transcribed DNA outside.
  • It is involved in chromosome positioning, replication, protection and control of cell growth and lifespan.
  • It is closely related to apoptosis, cell transformation and immortalization.

Repeated sequences in telomeres are useful candidates for synthetic telomere FISH probes, also known as TeloFISH probes.

Peptide nucleic acid (PNA) is a novel DNA analogue. PNA can recognize and bind DNA or RNA sequences to form a stable double helix structure.

PNA probes have additional advantages compared to DNA probes (Fig. 1).

Fig. 1 Parameter comparison of DNA and PNA.

Fig. 1 Parameter comparison of DNA and PNA.

PNAs are very effective as FISH probes, even at very low concentrations. PNA probe binds to the target sequence rapidly (within a few hours) with much less interfering background.

TelG is a G-rich telomeric probe designed to detect lagging strands (TTAGGG repeats).

TelC is a C-rich telomere probe designed to detect leading strands (TAACCC repeat).

Both TelC and TelG PNA telomere probes are apply to rat chromosomes, human and mouse.

For Research Use Only. Not For Clinical Use.