Polymer Nanoparticles and Carriers Strategy for PNA Delivery
Polymer nanoparticles are a kind of drug carrier with the characteristics of small particles, which can cross the biofilm barrier to reach specific parts of the human body that traditional drugs cannot reach, establishing a new route of administration.
Creative Peptides is an excellent service provider dedicated to providing a full range of PNA research services. Our system of polymer nanoparticle carrier solutions will help you optimize the cell delivery of PNA and promote their application in the treatment of diseases.
Three Kinds of Polymer Nanoparticles
The current nanoparticle materials used for drug delivery are mainly polymers because polymers have the advantages of large molecular weight, sustained release of drugs, and avoidance of toxic and side effects, and the representative polymers mainly include the following three.
PLGA Polylactic co-glycolic acid (PLGA) is a copolymer composed of a mixture of lactate and glycolate, and has been widely used for drug delivery due to its non-toxicity and complete biodegradability. PLGA is slowly degraded by the hydrolysis of its polyester backbone under physiological conditions, which can control the release of previously loaded molecular cargo.
Multi-functional Cationic Shell-Cross-Linked Knedel-Like Nanoparticlesare a class of cross-linked block copolymer micelles, which are obtained through a combination of free radical polymerization and ring-opening polymerization, chemical modification and self-assembly processes. Their applications are mainly focused on the intracellular delivery of nucleic acids.
Multi-application In recent years, some naturally occurring materials have been used to try to deliver PNA in cells, including chitosan, which is a copolymer composed of glucosamine and N-acetylglucosamine, can be obtained by deacetylation of chitin. However, it is necessary to functionally modify its skeleton with suitable units to overcome the problem of poor water solubility.
Customize the Polymer Nanoparticle Carrier
Our scientists have experience in synthesizing various polymer nanoparticles. We can assist in process optimization of existing protocols and develop new strategies to help solve PNA delivery problems. The following techniques are used to prepare the required polymer nanoparticles.
- Polymerization of monomers to form polymer nanoparticles.
- After the polymer is dispersed to form nanoparticles.
- The structured amphiphilic polymer self-assembles to form nanoparticles in aqueous medium.
Our Load PNA Strategies
We mainly adopt two methods of carrying PNA on polymer nanoparticles.
➢ Embedding method
In this method, PNA is added together with the monomer, and the PNA is embedded in the particles during the polymerization reaction, which has the characteristic of large drug loading.
➢ Adsorption method
The adsorption method is that after the polymerization reaction is completed, PNA enters the inside of the particle through adsorption.
Solution Process
- Feasibility demonstration. Carry out feasibility demonstration according to customer needs, formulate development plans for high feasibility, and plan time and funds.
- Development phase. Carry out development and research in accordance with the established plan, including detailed recording of experimental data and research and development progress, and regular reporting of results to customers.
- Product production and inspection. Carry out product production and final delivery effect inspection, and provide related inspection reports.
Our excellent experts provide a variety of flexible and reliable solutions to improve the cellular uptake effect of PNA. If you are interested in the above services, please feel free to contact us for more details.
Reference
- Volpi S.; et al. Multifunctional delivery systems for peptide nucleic acids. Pharmaceuticals. 2021, 14(1):14.
Notice: Products and services are used only for scientific research.
