PNA Oligomer Synthesis
Creative Peptides team has accumulated rich experience in PNA chemistry, we can provide two chemical synthesis methods to synthesize PNA oligomers, including Boc chemistry and Fmoc chemistry. The entire synthesis process will be implemented in accordance with strict quality control protocols, and we are committed to synthesizing high-quality, high-precision, and high-activity PNA products to meet customer expectations.
About PNA Oligomer Synthesis
PNA is a pseudo-peptide backbone instead of the ribonucleic acid-phosphate backbone, retaining the original 4 bases. Nielsen et al in Rose Laboratory of the University of Copenhagen used a simple computer DNA model to successfully design and synthesize PNA and PNA in 1991. The synthesis of PNA is first to synthesize the monomers, and then oligomerize the PNA monomers according to the standard peptide synthesis method. The structural unit of PNA is modified amino acid, so it can be prepared in large quantities by peptide synthesis, and it can also be prepared by chemical synthesis by attaching functional groups to the N-terminus or C-terminus. PNA oligomers are prepared from protected PNA monomers by solid-phase synthesis, and their protection strategies, condensation conditions, deprotection methods and purification methods are similar to those of peptide synthesis.
Provide Services of Two Synthesis Routes
Synthesis of PNA Oligomers by Boc Chemistry
Synthesis of PNA Oligomers by Fmoc Chemistry
Problems in the Synthesis of PNA
- Components are expensive.
- There are many difficult sites for synthesis. When the PNA polyamide framework forms an amide bond, the protecting group is prone to steric hindrance.
- The purity of the monomer used has a great impact on the biological activity of the target PNA.
Product is identified and analyzed, and HPLC and MS analysis data are provided.
monomer raw materials to ensure the refined purity of synthetic samples.
improvement of purity, the biological activity of the target PNA is guaranteed.
Creative Peptides is committed to becoming a reliable and professional partner you can rely on, providing you with first-class services, accelerating project progress and maximizing your project success rate. You can contact us if you have any needs, we will solve your doubts and provide detailed information.
Notice: Products and services are used only for scientific research.