Antibacterial PNA Targeting Ribosomes Development
Creative Peptides has many years of development experience, a team of experts with rich industrial experience, advanced scientific research equipment and proprietary methods. We can provide a one-stop service for your antibacterial PNA development and preparation for different targets including ribosomes, and accelerate your drug development process.
Ribosome as Target of PNA
Many antibiotics exert antibacterial effects by binding to bacterial ribosomes and interfering with protein synthesis. The three-dimensional structure of bacterial ribosomes indicates that rRNA may be a target of PNA oligomers. PNA targeting the accessible and functionally important regions of ribosomal RNA may weaken the function of ribosomes. Therefore, once PNA is ingested by bacteria, it can produce antibacterial effects. Looking for targets in the ribosomal RNA ring region, two targets were identified.
- Target on 23S rRNA
- Target on 16S rRNA
Antibacterial PNA Targeting Ribosomes Development
Here are some antibacterial PNA sequences with ribosomes as the target. They can show a good effect on inhibiting the growth of bacteria and can be used as a reference case for customers to develop antibacterial PNA with ribosomes as the target.
Table.1 Development of PNA targeting ribosomes of bacteria (Wojciechowska M.; et al.2020)
Target | Function | Bacteria | MIC (μM) |
|---|---|---|---|
PTC | Peptidyl transferase center 23S rRNA | Escherichia coliK-12 | 50 |
a-sarcin loop | Binds elongation factor G (EF-G) 23S rRNA | Escherichia coliK-12 | 50 |
Helix 69 | Forms connection between ribosomal subunits | Escherichia coliK-12 | 15 |
mRBS | mRNA binding site 16S rRNA | Corynebacterium efficiens | 2 |
830−839 16S RNA | Part of IF3 binding site 16S rRNA | Escherichia coliK-12 | 15 |
Services
- We customize the most suitable strategy to find PNA against bacteria to meet every need of our customers, provide development services for the following bacteria, including but not limited to: Pseudomonas, Streptococcus, Enterococcus, Staphylococcus, Mycobacterium.
- Creative Peptides provides the best quality service in the production of antibacterial PNA. Through our professional platform, customers can get high-quality products, while reducing project costs and time, thereby accelerating their research.
Our Solutions
Regarding the technology and direction of the development of antibacterial PNA drugs targeting ribosomes, we mainly provide the following two ideas.
-
Chemical composition method
The chemical composition method is used to develop PNA drugs, and many PNA products have been successfully developed through solid phase composition and fragment linkage.
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Modification of existing PNA drugs
Modification of the structure of existing PNA drugs to overcome the shortcomings of the original products, reduce side effects is also a way to develop new PNA drugs.
Highlights
- Many years of service experience, many projects delivered to customers.
- Design solutions for multiple targets.
- One-stop service for development and production.
- Guarantee that it will be ready for use upon delivery.
- Good experimentation and record compliance.
- Super high success rate. Ensure successful use in the development of antibacterial drugs.
Creative Peptides is committed to using superior methods and technologies to develop antibacterial PNAs against different bacteria. We provide the best services to assist customers in developing and producing high-efficiency and high-quality antimicrobial PNA drugs at the most competitive cost. Please contact us for more information and detailed quotation.
Reference
- Wojciechowska M.; et al.Antibacterial peptide nucleic acids—facts and perspectives. Molecules. 2020, 25(3):559.
Notice: Products and services are used only for scientific research.
