Inorganic Nanocarriers Strategy for PNA Delivery
Inorganic nanomaterials have become ideal materials for drug delivery systems due to their good stability, excellent biocompatibility and high drug loading capacity. Creative Peptides provides solutions for the application of commonly used inorganic nanomaterials such as silica nanoparticles and porous silicon nanoparticles in PNA delivery, and promotes the application of inorganic nanocarriers in the development of PNA drugs.
Applications of Inorganic Nanocarriers in PNA Delivery
Porous inorganic nanocarriers can be dispersed in water and have a suitable size, and can be used for co-delivery of different types of molecules, because their cavities can contain small drugs and can be decorated with elements that can recognize biological macromolecules on their surfaces. We have listed some examples of inorganic nanocarriers that have been used for PNA delivery for reference.
| Type of inorganic nanocarriers | Type of PNA | Delivery procedure |
|---|---|---|
| Zeolite-L nanocrystals | PNA derivatives | PNA derivatives are covalently attached to the surface of zeolite-L nanocrystals and co-delivered with small molecules such as DAPI, which are released after PLL degradation. |
| Mesoporous silica nanoparticles | Anti-miR221 PNA | PNA is adsorbed to MSNP loaded with the chemotherapeutic agent temozolomide. |
| Porous silicon nanomaterials | Anti-miR122 PNA | The anti-miR122 PNA was loaded into pSiNPs by physical adsorption, and then the particles were electrostatically coated with the polymer PEG-DB. |
| 2D Mg-Al layered double hydroxides | PNA targeting KRAS G12D mutant gene | When the two are combined, the proton sponge effect produced by the nanoparticles occurs and promotes the release of PNA from the endosome. |
Synthetic Strategy
Although the chemical composition of inorganic nanoparticles is quite different, their synthesis methods have many similarities. We mainly provide two methods for the synthesis of inorganic nanocarriers and PNA.
Chemical conjugation
Most PNAs can be directly bonded to the coating molecules or polymer scaffolds on the surface of nanoparticles. Molecular linkers are usually combined with nanocarriers, and molecular linkers can be degraded by enzymatic cleavage, hydrolysis or heating.
Physical adsorption
PNA can be encapsulated in a nanotube carrier through hydrophobic interaction, electrostatic interaction or physical capture, and the encapsulated PNA can be released after the disintegration of nanoparticles triggered by cellular uptake or external signals.
Our Solutions
- Choose your target PNA. We can provide PNA design and synthesis services, and you can also tell us your customized plan and we will help you execute it.
- Determine the choice of inorganic nanocarriers. Creative Peptides will help select and synthesize the most suitable inorganic nanoparticles as its carrier according to your target PNA.
- Optimize sensitivity and potential stability. Through chemical processing, functionalization strategies and other means to optimize the sensitivity and stability of the overall conjugate, reduce toxicity.
Advantages
➢ With years of experience in PNA vector development, Creative Peptides ' scientists are committed to providing stable, sensitive, and reproducible final conjugates, which may be the most valuable feasible service.
➢ We provide construction services for PNA targeting and delivery systems based on nanoparticles. Targeting carriers can overcome the shortcomings of poor biodistribution, lack of selectivity, and serious side effects.
Please fill in our inquiry information and contact us to discuss your project, we are happy to provide you with a customized quotation.
Reference
- Bao G; et al. Multifunctional nanoparticles for drug delivery and molecular imaging. Annual review of biomedical engineering. 2013, 15(1):253-282.
Notice: Products and services are used only for scientific research.
