Modification of Purine Bases

Modification of Purine Bases

At Creative Peptides , we use unparalleled expertise and advanced technology to significantly improve laboratory performance. With professional knowledge, our well-trained staff can bring clarity and predictability to the design and analysis of research trials, advanced analytics and automated workflows can increase efficiency and improve quality.

Creative Peptides provides our customers with a wide range of professional services, starting with different base modifications to help advance the progress of PNA modification. We attach great importance to quality control and quality assurance, and are committed to careful planning, efficient and high-quality completion of our services.

Purine Bases

The structure of purine bases

Generally, the nucleobase is a convenient modification site, which can lead to many possible substitutions through accessible chemical methods. At present, many new PNA analogues have been synthesized, but the most commonly used is the classical PNA monomer, which provides a reasonable balance between the high affinity requirements for natural nucleic acids and the specificity of sequence recognition. Among the four bases A, T, C and G of four base of DNA, the synthesis of guanine acetic acid derivatives is more complex, and its modification is challenging, people mainly study the modification of adenine. Modifications of purine bases led to the development of 2, 6-diaminopurine applied to the design of pseudo-complementary PNA.

Modification Examples

Here are some common examples of purine base modifications.

Purine base type




Applied to the design of pseudo-complementary PNA

The structure of modification of nucleobases in PNA monomers


As a fluorescent probe for examining PNA–DNA interaction dynamics 

The structure of modification of nucleobases in PNA monomers


Form Watson–Crick base pairs with adenine, cytosine, thymine, and uracil increasing the specificity of PNA

The structure of modification of nucleobases in PNA monomers


Cause helix distortion at the 6sG:C base pair, the base stacking throughout the duplex was still retained 

The structure of modification of nucleobases in PNA monomers

Our Advantages

  • Our well-trained experts have extensive experience in PNA research, as well as extensive capabilities to handle complex customized services, and cooperate with our customers to complete development trials.
  • Our highly flexible configurable workflow can meet the unique requirements of your products, as well as effective procedures and methods to ensure high-quality services.
  • Our tailor-made solutions include PNA development design, synthesis and modification, and product production to meet your complex and unique needs throughout the development cycle.

Creative Peptides is committed to providing a full range of PNA development services. We insist on integrity and professionalism to win the trust and cooperation of customers. Please feel free to contact us for more information about our services.


  • Wojciechowska, M.et al.Antibacterial peptide nucleic acids-facts and perspectives. Molecules.2020, 25(3), 559.

Notice: Products and services are used only for scientific research.