PNA Synthesis Reagents
Creative Peptides' PNA spacers and solutions provide flexible and efficient solutions for a wide range of applications.
Browse our catalog below to find your products of interest.
Structure | Product Name / CAS / Cat | Description / Size | Price |
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Ethyl N-(Boc-Aminoethyl)Glycinate HCl
CAS:72648-80-7 Catalog:PR-009 |
Formula:C11H23N2O4Cl Formula Weight:282,76 Size:1 g/10 g/25 g/50 g/>50 g |
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N-[N'-Fmoc-(2'-aminoethyl)]Gylcine
CAS:PR-010 Catalog:PR-010 |
Formula:C19H20N2O4 Formula Weight:340,34 Size:1 g/10 g/25 g/50 g/>50 g |
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N-[N'-Fmoc-(2-aminoethyl)]Glycine Tert-Butylester HCl
CAS:169396-88-7 Catalog:PR-011 |
Formula:C23H29N2O4Cl Formula Weight:432,95 Size:1 g/10 g/25 g/50 g/>50 g |
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1-[Bis(Dimethylamino)Methylene]-1H-1,2,3-Triazolo[4,5-b]Pyridinium 3-Oxide Hexafluorophosphate
CAS:148893-10-1 Catalog:PR-012 |
Formula:C10H15F6N6OP Formula Weight:380,23 Size:10 g/50 g/100 g/250 g/500 g/1 kg/> 1 kg |
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2-Amino-N-Isopropylacetamide HCl
CAS:614718-86-4 Catalog:PR-013 |
Formula:C5H13N2OCl Formula Weight:152,62 Size:10 g/50 g/100 g/250 g/500 g/1 kg/> 1 kg |
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(Cytosine-1-Yl)-Acetic Acid
CAS:50615-65-1 Catalog:PR-014 |
Formula:C6H7N3O3 Formula Weight:169.14 |
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2-Amino-6-Chloro-9H-Purine-9-Acetic Acid
CAS:149376-70-5 Catalog:PR-015 |
Formula:C7H6ClN5O2 Formula Weight:227.61 |
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2-Thiouracil(P-Methoxybenzyl) Acetic Acid
CAS:253439-01-9 Catalog:PR-016 |
Formula:C14H14N2O4S1 Formula Weight:306.34 |
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5-Carboxytetramethylrhodamine Succinimidyl Ester
CAS:150810-68-7 Catalog:PR-017 |
Formula:C29H25N3O7 Formula Weight:527.52 |
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Adenine-Boc Acetic Acid
CAS:186046-99-1 Catalog:PR-018 |
Formula:C12H15N5O4 Formula Weight:293.28 Size:1 g/5 g/10 g |
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CBZ-Diaminopurine Acetic Acid
CAS:202343-71-3 Catalog:PR-019 |
Formula:C17H18N6O4 Formula Weight:370.36 |
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Cytosine-1-Acetic Acid Ethyl Ester
CAS:55175-48-9 Catalog:PR-020 |
Formula:C8H11N3O3 Formula Weight:197.19 |
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Cytosine-Boc Acetic Acid
CAS:172405-16-2 Catalog:PR-021 |
Formula:C11H15N3O5 Formula Weight:269.25 Size:1 g/5 g/10 g |
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Ethyl A Denine-9-Acetate
CAS:25477-96-7 Catalog:PR-022 |
Formula:C9H11N5O2 Formula Weight:221.22 |
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Fmoc-Aea-OH
CAS:260367-12-2 Catalog:PR-023 |
Formula:C19H19NO5 |
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Fmoc-Aeea-OH Spacer
CAS:166108-71-0 Catalog:PR-024 |
Formula:C21H23NO6 Formula Weight:385.42 |
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Fmoc-Aeg-OH.HCl
CAS:172405-45-7 Catalog:PR-025 |
Formula:C19H21Cl1N2O4 Formula Weight:384.38 Size:1 g/5 g/10 g |
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Fmoc-Aeg-OMe.HCl
CAS:172405-43-5 Catalog:PR-026 |
Formula:C20H23Cl1N2O4 Formula Weight:390.86 Size:1 g/5 g/10 g |
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Guanine-Boc Acetic Acid
CAS:1028077-12-4 Catalog:PR-027 |
Formula:C12H15N5O5 Formula Weight:309.28 Size:1 g/5 g/10 g |
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J-Acetic Acid Methyl Ester
CAS:163081-06-9 Catalog:PR-028 |
Formula:C7H9N3O3 Formula Weight:183.16 |
Introduction
Peptide nucleic acids (PNA) are novel structural analogs of DNA and are effective and stable antisense and antigene agents. PNA can specifically bind to nucleic acids with high affinity and high biological stability and is not easily degraded by nucleases and proteases. The regulation of transcription and translation by PNA can effectively inhibit oncogene expression, viral gene replication and transcription, thus showing its promising application in gene therapy.
Fig. 1 Structure of PNA (Burnham M, 2004)
Pair-binding Properties of PNA
- stability. After the hybridization of PNA with target sequence DNA or RNA molecules, the melting temperature of the complexes increases accordingly.
- Non-dependence on salt concentration. The stability of the duplex structure formed by PNA/DNA hybridization is independent of the salt concentration of the medium.
- Specificity. The hybridization and binding of PNA to complementary DNA showed high specificity.
Role of PNA
- Regulates the transcriptional processes. PNA can inhibit the binding of polymerase or transcription factors to the template, thereby affecting transcription and replication without affecting the action of the polymerase itself, or it can inhibit transcription by preventing the extension of the RNA strand.
- Regulates the translation process. The PNA-RNA double helix inhibits translation initiation, the PNA2-RNA trimer structure inhibits translation elongation, and neither PNA-RNA nor PNA2-RNA trimer is a substrate for RNase H.
- Inhibits expression of reverse transcription-regulated genes. PNA can inhibit the reverse transcription of mRNA into cDNA, and the spatial hindrance effect of PNA can selectively inhibit reverse transcription without affecting translation in a certain concentration range.
Applications of PNA
- Antisense drugs
- Antigene drugs
- Gene delivery vectors
- Inducers of endogenous gene expression
PNA has become a new class of powerful tools for molecular biology research and has a wide range of applications in gene expression, regulatory PCR amplification, molecular hybridization, gene mutation analysis, telomerase length analysis, and gene diagnosis and gene therapy for genetic diseases, tumors, viral infections and other diseases. Creative Peptides provides its customers with PNA synthesis reagents consisting mainly of spacers and other solutions.
Reference
- Burnham M; et al. Antisense peptide nucleic acids in antibacterial drug discovery. Mol Ther. 2004 Oct; 10(4): 614-5.
For Research Use Only. Not For Clinical Use.