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PNA Synthesis Reagents

PNA Synthesis Reagents

Creative Peptides provides PNA synthesis reagents mainly including spacers and other solutions. Click here to learn more!

Browse our catalog below to find your products of interest.

Structure Product Name / CAS / Cat Description / Size Price
Ethyl N-(Boc-Aminoethyl)Glycinate HCl
CAS:347890-34-0
Catalog:PR-009

Formula:C11H23N2O4Cl
Formula Weight:282,76
Size:1 g/10 g/25 g/50 g/>50 g
N-[N'-Fmoc-(2'-aminoethyl)]Gylcine
CAS:172405-45-7
Catalog:PR-010

Formula:C19H20N2O4
Formula Weight:340,34
Size:1 g/10 g/25 g/50 g/>50 g
N-[N'-Fmoc-(2-aminoethyl)]Glycine Tert-Butylester HCl

Catalog:PR-011

Formula:C23H29N2O4Cl
Formula Weight:432,95
Size:1 g/10 g/25 g/50 g/>50 g
1-[Bis(Dimethylamino)Methylene]-1H-1,2,3-Triazolo[4,5-b]Pyridinium 3-Oxide Hexafluorophosphate
CAS:148893-10-1
Catalog:PR-012

Formula:C10H15F6N6OP
Formula Weight:380,23
Size:10 g/50 g/100 g/250 g/500 g/1 kg/> 1 kg
2-Amino-N-Isopropylacetamide HCl
CAS:614718-86-4
Catalog:PR-013

Formula:C5H13N2OCl
Formula Weight:152,62
Size:10 g/50 g/100 g/250 g/500 g/1 kg/> 1 kg
(Cytosine-1-Yl)-Acetic Acid
CAS:50615-65-1
Catalog:PR-014

Formula:C6H7N3O3
Formula Weight:169.14
2-Amino-6-Chloro-9H-Purine-9-Acetic Acid
CAS:149376-70-5
Catalog:PR-015

Formula:C7H6ClN5O2
Formula Weight:227.61
2-Thiouracil(P-Methoxybenzyl) Acetic Acid

Catalog:PR-016

Formula:C14H14N2O4S1
Formula Weight:306.34
5-Carboxytetramethylrhodamine Succinimidyl Ester
CAS:150810-68-7
Catalog:PR-017

Formula:C29H25N3O7
Formula Weight:527.52
Adenine-Boc Acetic Acid

Catalog:PR-018

Formula:C12H15N5O4
Formula Weight:293.28
Size:1 g/5 g/10 g
CBZ-Diaminopurine Acetic Acid

Catalog:PR-019

Formula:C17H18N6O4
Formula Weight:370.36
Cytosine-1-Acetic Acid Ethyl Ester

Catalog:PR-020

Formula:C8H11N3O3
Formula Weight:197.19
Cytosine-Boc Acetic Acid
CAS:172405-16-2
Catalog:PR-021

Formula:C11H15N3O5
Formula Weight:269.25
Size:1 g/5 g/10 g
Ethyl A Denine-9-Acetate
CAS:25477-96-7
Catalog:PR-022

Formula:C9H11N5O2
Formula Weight:221.22
Fmoc-Aea-OH
CAS:260367-12-2
Catalog:PR-023

Formula:C19H19NO5

Fmoc-Aeea-OH Spacer

Catalog:PR-024

Formula:C21H23NO6
Formula Weight:385.42
Fmoc-Aeg-OH.HCl

Catalog:PR-025

Formula:C19H21Cl1N2O4
Formula Weight:384.38
Size:1 g/5 g/10 g
Fmoc-Aeg-OMe.HCl
CAS:172405-43-5
Catalog:PR-026

Formula:C20H23Cl1N2O4
Formula Weight:390.86
Size:1 g/5 g/10 g
Guanine-Boc Acetic Acid
CAS:1028077-12-4
Catalog:PR-027

Formula:C12H15N5O5
Formula Weight:309.28
Size:1 g/5 g/10 g
J-Acetic Acid Methyl Ester

Catalog:PR-028

Formula:C7H9N3O3
Formula Weight:183.16

Introduction

Peptide nucleic acids (PNA) are novel structural analogs of DNA and are effective and stable antisense and antigene agents. PNA can specifically bind to nucleic acids with high affinity and high biological stability and is not easily degraded by nucleases and proteases. The regulation of transcription and translation by PNA can effectively inhibit oncogene expression, viral gene replication and transcription, thus showing its promising application in gene therapy.

PNA Synthesis ReagentsFig. 1 Structure of PNA (Burnham M, 2004)

Pair-binding Properties of PNA

  • stability. After the hybridization of PNA with target sequence DNA or RNA molecules, the melting temperature of the complexes increases accordingly.
  • Non-dependence on salt concentration. The stability of the duplex structure formed by PNA/DNA hybridization is independent of the salt concentration of the medium.
  • Specificity. The hybridization and binding of PNA to complementary DNA showed high specificity.

Role of PNA

  • Regulates the transcriptional processes. PNA can inhibit the binding of polymerase or transcription factors to the template, thereby affecting transcription and replication without affecting the action of the polymerase itself, or it can inhibit transcription by preventing the extension of the RNA strand.
  • Regulates the translation process. The PNA-RNA double helix inhibits translation initiation, the PNA2-RNA trimer structure inhibits translation elongation, and neither PNA-RNA nor PNA2-RNA trimer is a substrate for RNase H.
  • Inhibits expression of reverse transcription-regulated genes. PNA can inhibit the reverse transcription of mRNA into cDNA, and the spatial hindrance effect of PNA can selectively inhibit reverse transcription without affecting translation in a certain concentration range.

Applications of PNA

  • Antisense drugs
  • Antigene drugs
  • Gene delivery vectors
  • Inducers of endogenous gene expression

PNA has become a new class of powerful tools for molecular biology research and has a wide range of applications in gene expression, regulatory PCR amplification, molecular hybridization, gene mutation analysis, telomerase length analysis, and gene diagnosis and gene therapy for genetic diseases, tumors, viral infections and other diseases. Creative Peptides provides its customers with PNA synthesis reagents consisting mainly of spacers and other solutions.

Reference

  • Burnham M; et al. Antisense peptide nucleic acids in antibacterial drug discovery. Mol Ther. 2004 Oct; 10(4): 614-5.

For Research Use Only. Not For Clinical Use.