Creative Peptides provides various reagents related to PNA synthesis and operation.
- PNA Intermediates
- PNA Bases
- PNA Synthesis Reagents
This mainly includes the intermediate materials required for the PNA synthesis process.
This mainly includes the bases needed in the process of PNA synthesis.
This mainly includes the spacers and other reagents needed for PNA synthesis.
Peptide nucleic acid (PNA) is a novel DNA analog with a peptide backbone. PNA is synthesized artificially. No known individual organisms on Earth have been found to possess PNA in their bodies. The backbone of PNA is composed of repeatedly arranged N-(2-aminoethyl)-glycine units, which are assembled by peptide bonds. The bases are linked to the backbone by methylene carbonyl bonds. PNA also has an N-terminal (nitrogen-terminals) and a C-terminal (carbon-terminals).
Fig. 1 Structure of DNA and PNA.
Characteristics of PNA
- PNA molecules have structural characteristics similar to those of natural DNA molecules
- PNA can form dimers of target genes
- PNA has the same characteristics of binding to specific DNA and RNA molecules as oligonucleotides
- PNA works by forming a three-stranded helix structure with target genes
Advantages of PNA
- PNA can be synthesized from monomers
- Resistant to degradation by nucleases and proteases
- Good water solubility and stability
- PNA requires a shorter sequence length than DNA
- PNA binding to DNA requires only a low salt reaction environment
Application of PNA
- miRNA inhibitors
- Double-stranded DNA invasion and capture
- Microarray probes
- For fluorescence in situ hybridization (FISH) analysis
- Sequence-specific PCR inhibitors (PNA clamps)
- Genome excision and mapping analysis
- Gene expression regulation
- As antisense drugs
Notice: Products and services are used only for scientific research.