PNA Reagents

PNA Reagents

Creative Peptides provides various reagents related to PNA synthesis and operation.

Our Products

  • PNA Intermediates
  • This mainly includes the intermediate materials required for the PNA synthesis process.

  • PNA Bases
  • This mainly includes the bases needed in the process of PNA synthesis.

  • PNA Synthesis Reagents
  • This mainly includes the spacers and other reagents needed for PNA synthesis.


Peptide nucleic acid (PNA) is a novel DNA analog with a peptide backbone. PNA is synthesized artificially. No known individual organisms on Earth have been found to possess PNA in their bodies. The backbone of PNA is composed of repeatedly arranged N-(2-aminoethyl)-glycine units, which are assembled by peptide bonds. The bases are linked to the backbone by methylene carbonyl bonds. PNA also has an N-terminal (nitrogen-terminals) and a C-terminal (carbon-terminals).

Structure of DNA and PNA.

Fig. 1 Structure of DNA and PNA.

Characteristics of PNA

  • PNA molecules have structural characteristics similar to those of natural DNA molecules
  • PNA can form dimers of target genes
  • PNA has the same characteristics of binding to specific DNA and RNA molecules as oligonucleotides
  • PNA works by forming a three-stranded helix structure with target genes

Advantages of PNA

  • PNA can be synthesized from monomers
  • Resistant to degradation by nucleases and proteases
  • Good water solubility and stability
  • PNA requires a shorter sequence length than DNA
  • PNA binding to DNA requires only a low salt reaction environment

Application of PNA

  • miRNA inhibitors
  • Double-stranded DNA invasion and capture
  • Microarray probes
  • For fluorescence in situ hybridization (FISH) analysis
  • Sequence-specific PCR inhibitors (PNA clamps)
  • Genome excision and mapping analysis
  • Gene expression regulation
  • As antisense drugs

Notice: Products and services are used only for scientific research.