Antiviral PNA Development for Other Viruses
Using the translational and anti-gene properties of PNA as a tool to regulate gene expression, it is possible to develop PNA therapeutic drugs against different viruses. Creative Peptides not only targets the hepatitis virus, influenza virus, and HIV that have been more studied, but also provides PNA drug development services for other viral diseases.
Japanese Encephalitis Virus
Japanese encephalitis virus (JEV) is spherical and the nucleic acid is single-stranded RNA. JEV enters the human body, proliferates in phagocytes such as vascular endothelial cells, lymph nodes, liver, and spleen, and reaches the brain through blood circulation, causing inflammation.
The sites that can be targeted during PNA design include but are not limited to the following:
- 5'-untranslated region
- TR
- 3'-UTR
- 5'- and 3'- cyclization
Severe Acute Respiratory Syndrome Coronavirus
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) has a spherical shape and is an enveloped single-stranded positive-stranded RNA virus. It is the largest known RNA virus. SARS-CoV has been shown to be a zoonotic disease that has evolved in civet cats and human hosts. This is the first highly contagious disease to appear in the 21st century.
Designing antisense PNA for the pseudoknot domain in the -1 programmed ribosomal frameshifting (-1 PRF) signal showed a significant effect of inhibiting virus replication.
Porcine Epidemic Diarrhea Virus
Porcine Epidemic Diarrhea Virus (PEDV) is a deadly mysterious virus, which belongs to the coronavirus family. Since its emergence, this virus has not only caused disasters to the pig industry, but environmental experts are even more worried that dead pig carcasses will contaminate groundwater.
It is possible to design highly efficient and specific antisense PNA sequences against the conserved part of the gene in PEDV. By combining the target gene to induce the ribozyme to degrade the target gene, thereby blocking the transcription and expression of the target gene, and inhibiting the replication and assembly of PEDV in the body.
What Can We Do
Antivirus PNA development service
In response to various viral diseases, we have a variety of PNA development programs to explore different targets. Our scientists provide programs according to your requirements, which can be used to support drug development.
Customized PNA production service
We provide customized PNA production services, formulate quality control standards and quality management strategies that meet the requirements, ensure product safety, shorten production time and save costs, thereby speed up your research.
Advantages
- Advanced equipment and a highly professional technical team.
- Experience serving hundreds of customers around the world.
- PNA construction, process development, product production and other integrated high-quality services.
Creative Peptides is a leading PNA technology company focusing on the development of antiviral PNAs with high specificity and affinity for research and therapeutic purposes. The viruses we target include but are not limited to the above. If you are interested in any relevant directions, please contact us for specific consultation.
Reference
- Sun H.; et al.Application of peptide nucleic acid in virus detection and treatment. Chinese Journal of Bioengineering.2020, 152-159.
Notice: Products and services are used only for scientific research.
