Fmoc PNA Monomers

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Fmoc PNA Monomers

Fmoc PNA Monomers are Fmoc-protected iodoamine based nucleotide monomers that can be used for the synthesis of high purity, high performance PNA molecules.

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Structure	Product Name / CAS / Cat	Description / Size	Price
	Fmoc-A(Bhoc)-Aeg-OH CAS:186046-82-2 Catalog:FM-001	PNA monomer incorporating a A nucleobase analogue through the Fmoc protecting group Formula:C40H35N7O7 Formula Weight:725.75 Size:1 g/2 g/ 5 g/10 g/25 g
	Fmoc-C(Bhoc)-Aeg-OH CAS:186046-81-1 Catalog:FM-002	PNA monomer incorporating a C nucleobase analogue through the Fmoc protecting group Formula:C39H35N5O8 Formula Weight:701.72 Size:1 g/2 g/ 5 g/10 g/25 g
	Fmoc-G(Bhoc)-Aeg-OH CAS:186046-83-3 Catalog:FM-003	PNA monomer incorporating a G nucleobase analogue through the Fmoc protecting group Formula:C40H35N7O8 Formula Weight:741.75 Size:1 g/2 g/ 5 g/10 g/25 g
	Fmoc-J-(Boc)-Aeg-OH CAS:1095275-70-9 Catalog:FM-004	Formula:C30H33N5O8 Formula Weight:591.61 Size:1 g
	Fmoc-PNA-Maleimido Monomer CAS:FM-005 Catalog:FM-005	Formula:C26H25N3O7 Formula Weight:491.49
	Fmoc-T-Aeg-OH CAS:169396-92-3 Catalog:FM-006	PNA monomer incorporating a T nucleobase analogue through the Fmoc protecting group Formula:C26H26N4O7 Formula Weight:506.51 Size:1 g/5 g/10 g/25 g
	Fmoc-PNA-U-OH CAS:959151-70-3 Catalog:FM-007	PNA monomer incorporating a U nucleobase analogue through the Fmoc protecting group Formula:C25H24N4O5 Formula Weight:355.54
	G-clamp PNA Monomers CAS:FM-008 Catalog:FM-008	Formula:C51H48N8O12 Formula Weight:964.97
	Fmoc-Aeea-OH CAS:166108-71-0 Catalog:FM-009	Formula:C21H23NO6 Formula Weight:385.4 Size:1 g
	Fmoc-PNA-A(Boc)-OH CAS:511534-99-9 Catalog:FM-010	Formula:C31H33N7O7 Formula Weight:615.65 Size:1 g/5 g
	Fmoc-PNA-C(Boc)-OH CAS:172405-61-7 Catalog:FM-011	Formula:C30H33N5O8 Formula Weight:591.62 Size:1 g/5 g
	Fmoc-PNA-D(tetraBhoc)-OH Catalog:FM-012	Formula:C82H66N8O13 Formula Weight:1371.47 Size:1 g/5 g
	Fmoc-PNA-D(tetraBoc)-OH CAS:2101661-88-3 Catalog:FM-013	Formula:C46H58N8O13 Formula Weight:931.01 Size:1 g/5 g/10 g/25 g
	Fmoc-PNA-G(Boc)-OH CAS:1052677-90-3 Catalog:FM-014	Formula:C31H33N7O8 Formula Weight:631.65 Size:1 g/5 g
	Fmoc-PNA-J(Bhoc)-OH Catalog:FM-015	Formula:C39H35N5O8 Formula Weight:701.74 Size:1 g/5 g
	Fmoc-PNA-M(Bhoc)-OH Catalog:FM-016	Formula:C40H36N4O7 Formula Weight:684.75 Size:1 g/5 g
	Fmoc-PNA-M(Boc)-OH CAS:1417611-27-8 Catalog:FM-017	Formula:C31H34N4O7 Formula Weight:574.63 Size:1 g/5 g

Introduction

PNA is an oligonucleotide analog prepared by conventional solid-phase peptide synthesis (SPPS) techniques. Solid-phase synthesis-based t-Boc and Fmoc schemes are widely used. The Fmoc solution enhances high-quality synthetic products while avoiding the use of highly corrosive chemicals. As a result, Fmoc SPPS has become a commercially popular synthesis technique. The Fmoc group is significantly selective for the protection of aliphatic primary amines of PNA monomers, but the protection of this group against the extra-cyclic amino groups of nucleobases A, C and G must be determined. The protecting group must provide sufficient protection during the synthesis process. In addition, it should be easily removed under dissociative conditions and must exhibit sufficient solubility for the corresponding monomers. Bhoc is the best candidate. It allows the PNA monomer to be preserved in 0.2 mol/L NMP for several weeks. Bhoc can be removed in less than a minute with clean TFA.

The labeling of PNA is accomplished with the linking of the cross-linker to the amino terminus. PNA can be labeled directly at the amino terminals. But often an arm is added between the reporter gene and the probe so as not to interfere with hybridization. The most commonly used arm is the 8-amino-3,6-dioxaoctanoic acid known as O-monomer. Fmoc-AEEA-OH is hydrophilic. It has the advantage of improving the yield of labeling reactions and increasing the solubility of PNA in aqueous solutions.

Fig. 1 Structure of Fmoc-AEEA-OH.

Advantages of Our Products

High purity
High solubility
High reactivity
Reasonable price

Reference

Behrendt R; et al. Advances in Fmoc solid-phase peptide synthesis. J Pept Sci. 2016 Jan; 22(1): 4-27.

For Research Use Only. Not For Clinical Use.